In this abstract, we present an innovative platform which has several advantages to increase the efficiency of pharmaceutical research and development and that allows flexible bioprocess monitoring. A fiber optic surface plasmon resonance (FO-SPR) sensor was developed as a cost-effective and easy-to-use alternative for the expensive and more complex SPR systems. The FO-SPR sensor was already successfully demonstrated in numerous applications for protein, cells and DNA-based bioassays: therapeutic drug monitoring of biologicals, quantification of contaminants, hormones and pathogens in food, DNA mutation analysis, amplification and quantification. Measurements were done directly in 50% diluted blood/serum samples or food matrices (milk, chocolate), drastically reducing the sample preparation. Furthermore, the reaction kinetics of the specific biomolecular interactions, calculated with FO-SPR, are similar to the reference technologies. Moreover, time-to-result of the immunoassays (7-15 min) are comparable with lateral flow assays while PCR is combined with melting analysis in a one-step DNA-based assay. In summary, the innovative FO-SPR platform holds the capacity for: (i) quantifying small molecules, protein and DNA biomarkers, (ii) measuring the kinetics or activity of the bioreceptor-target (DNA-DNA, protein-protein, protein-cells and DNA-protein) binding reactions, (iii) fast turnaround times of the implemented bioassay and (iv) integration of signal amplification strategies with nanoparticles. The advantages of combining a simple-to-use and low cost instrument with fast responses, minimal sample preparation and automation render the FO-SPR technology as a flexible and reliable life science research and bioprocess monitoring instrument (www.FOxbiosystems.com).